Last updated on: 02/07/2019
Name of organisation
1) Department/Research group
2) Organisation/affiliationClinical Practice Research Datalink
Short Name in the inventoryCPRD
Administrative Contact
Title Ms
Last name Au
First name Sherlin
Address line 110 South Colonnade
Address line 2Canary Wharf
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
Phone number (incl. country code)44-2030-806383
Alternative phone number
Fax number (incl. country code)
Scientific Contact
Title Mr
Last name Daniel
First name Dedman
Address line 110 South Colonnade
Address line 2Canary Wharf
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
Phone number (incl. country code)44-2030-806383
Alternative phone number
Fax number (incl. country code)
Alternative Scientific Contact
Title Mrs
Last name Jennifer
First name Campbell
Address line 110 South Colonnade
Address line 2Canary Wharf
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
Phone number (incl. country code)44-2030-806383
Alternative phone number
Fax number (incl. country code)
2. Description
The Clinical Practice Research Datalink (CPRD - formerly GPRD) is the English NHS observational data and interventional research service, jointly funded by the NHS National Institute for Health Research (NIHR) and the Medicines and Healthcare products Regulatory Agency (MHRA). CPRD services are designed to maximise the way anonymised NHS clinical data can be linked to enable many types of observational research and deliver research outputs that are beneficial to improving and safeguarding public health.
CPRD is considered by many as the GOLD standard and its usage has resulted in over 1,500 clinical reviews and papers. The team at CPRD provides value-added services to the General Practitioners who contribute to the database and to the researchers who want to make use of this unique public health research tool.
3. Category
Government based
4. Available resources
In houseVia Contacts/Network
5. Therapeutic/disease areas of research in drug safety/risk-benefit performed in the past 5 years
Cardiovascular diseases
Congenital Malformations
Devices
Disorders of the central nervous system
Ear, nose and oropharynx disorders
Endocrine disorders
Eye disorders
Gastrointestinal tract
Geriatrics
Gynaecology
Immunological products and vaccines
Immunosuppression
Infectious diseases
Liver disease
Malignant disease
Musculoskeletal and joint diseases
Nutrition and blood
Osteoporosis
Paediatrics
Poisoning/Overdose
Pregnancy
Psychiatry
Renal impairment
Respiratory diseases
Skin disorders
Urinary tract disorders
6. Design of drug safety/risk-benefit studies published in the past 5 years
Cohort Study
Case Control Study
Drug Utilisation
Interventional Clinical Trial
Meta-Analysis
Risk benefit
PAS
7. Experience in collecting data directly from individual patients/respondents
Number of Studies
Greater than 5
Number of patients/respondents involved in the study(ies)
Between 150 and 1499
8. Access to data collection resources
Capacity to conduct face-to-face interviews
Yes
In a clinic
No
In the community
Yes
Electronic data capture systems
Yes
System used:
in house (CPRD)
Interactive voice response systems
No
Call centre
Yes
9. Experience in secondary research and meta-analysis
Yes
10. Work with existing data resources in the past 3 years
Name of data resourceNo. of studies
CPRD200
GPRD200
Hospital Treatment Insights - UK1
IMS Health1
PHARMO Database Network1
11. Registries established by centre
Drug Registryprospective research within CPRD
Disease Registryprospective research within CPRD
12. Experience in collaboration in a study team
Principal Investigator
Collaborating Investigator
13. Current involvement in research networks
Other networks:
Network nameNationalInternationalLink to webpage
Various European collaborations
No
Yes
Various UK funded studies
Yes
No
14. Interest in research opportunities which are funded
By pharmaceutical companies
By charities
By government
By research councils
By EU funding schemes
15. Interest in contract research only if free to publish results
Yes
16. Selected publications of the last 5 calendar years
ReferenceLink to web-publication
Herrett E, Shah AD, Boggon R, Denaxas S, Smeeth L, van Staa T, Timmis A, Hemingway H. Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study. BMJ. 2013 May 20;346:f2350.http://www.cprd.com/Bibliography/
Boggon R, van Staa TP, Chapman M, Gallagher AM, Hammad TA, Richards MA. Cancer recording and mortality in the General Practice Research Database and linked cancer registries. Pharmacoepidemiol Drug Saf. 2013 Feb;22(2):168-75.http://www.cprd.com/Bibliography/
Kousoulis AA, Rafi I, de Lusignan S. The CPRD and the RCGP: building on research success by enhancing benefits for patients and practices. Br J Gen Pract. 2015 Feb;65(631):54-5.
http://www.cprd.com/Bibliography/
van Staa TP et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol Assess. 2014 Jul;18(43):1-146.http://www.cprd.com/Bibliography/
Herrett E, Gallagher AM, Bhaskaran K, Forbes H, Mathur R, van Staa T, Smeeth L. Data Resource Profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol. 2015 Jun;44(3):827-36.http://www.cprd.com/Bibliography/
