Status: PlannedLast updated on: 29/06/2017
1. Study identification
EU PAS Register NumberEUPAS19636
Official titleReproducible Evidence: Practices to Enhance and Achieve Transparency
Study title acronymREPEAT
Study typeObservational study
Brief description of the studyLarge healthcare database research informs both clinical and payment decisions as well as improves the quality and affordability of healthcare for public health. Interest and capacity to use data contained in large healthcare databases has increased exponentially, however, much of the evidence from those valuable large healthcare databases suffers from lack of reproducibility, transparency and scientific robustness. This project aims to evaluate the current state of reproducibility of large published healthcare database studies. We will achieve this objective by taking a systematic random sample of healthcare database studies published in a leading clinical or epidemiology journal within the last 5 years and attempting to reproduce them based on the reported methods in publications and appendices. We plan to sample studies that were conducted using different large healthcare data sources.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre nameN/A
Centre locationN/A
Details of (Primary) lead investigator
Title Dr
Last name Wang
First name Shirley
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)

Countries in which this study is being conducted
National study

United States
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed01/08/2017
Start date of data collection01/08/2017
Start date of data analysis01/08/2018
Date of interim report, if expected
Date of final study report01/08/2019
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
CharitiesLaura and John Arnold Foundation100
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Dr
Last name Wang
First name Shirley
Address line 11 Brigham Circle
Address line 2Suite 3030 
Address line 3 
CityBoston, MA 
Postcode02120 
CountryUnited States
Phone number (incl. country code)1-6175258376 
Alternative phone number 
Fax number (incl. country code)1-6172328602 
Email address swang1@bwh.harvard.edu
Public Enquiries
Title Dr 
Last name Wang 
First name Shirley 
Address line 11 Brigham Circle 
Address line 2Suite 3030 
Address line 3 
CityBoston, MA 
Postcode02120 
CountryUnited States 
Phone number (incl. country code)1-6175258376 
Alternative phone number 
Fax number (incl. country code)1-6172328602 
Email address swang1@bwh.harvard.edu 
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