Status: Ongoing First registered on: 23/02/2015
Last updated on: 18/12/2018
1. Study identification
EU PAS Register NumberEUPAS8705
Official titleBenzodiazepine and anticholinergic use and incident dementia
Study title acronymABCD study
Study typeObservational study
Brief description of the studyIn this study we will examine whether the use of benzodiazepines, non-benzodiazepine derivates and medications with anticholinergic activity increase the risk of dementia. We will also examine whether the risk persists or is reduced once the medication is stopped. We will identify CPRD patients who, since April 2006, were diagnosed with dementia aged 65-99 years. We will compare the medication history of each patient with dementia to that of 7 matched patients without dementia. We will compare the use and dosage of medications prescribed during the period before dementia diagnosis, whilst controlling for other health and social differences.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre nameUniversity of East Anglia
Centre locationNorwich, UK
Details of (Primary) lead investigator
Title Dr
Last name George
First name Savva
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)

Countries in which this study is being conducted
National study

United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed30/06/2014
Start date of data collection03/07/2015
Start date of data analysis24/08/201526/10/2015
Date of interim report, if expected
Date of final study report30/09/2018
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
CharitiesAlzheimer's Society100
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Dr
Last name Richardson
First name Kathryn
Address line 1School of Health Sciences
Address line 2The Queen's Building 
Address line 3University of East Anglia 
CityNorwich 
PostcodeNR4 7TJ 
CountryUnited Kingdom
Phone number (incl. country code)441603591070 
Alternative phone number 
Fax number (incl. country code) 
Public Enquiries
Title Dr 
Last name George 
First name Savva 
Address line 1School of Health Sciences 
Address line 2Edith Cavell Building 
Address line 3University of East Anglia 
CityNorwich 
PostcodeNR4 7TJ 
CountryUnited Kingdom 
Phone number (incl. country code)441603597091 
Alternative phone number 
Fax number (incl. country code) 
Email address G.Savva@uea.ac.uk 
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