Status: Finalised First registered on: 20/12/2016
Last updated on: 17/10/2018
1. Study identification
EU PAS Register NumberEUPAS16875
Official titleInvestigating the possible role of BLood eosinophil counts in guiding ANti-inflammatory treatment of COPD exAcerbations (BLANCA)
Study title acronym
Study typeObservational study
Brief description of the studyA matched historical database study among patients with COPD in the UK will be conducted. The index date is defined as the date of any exacerbation with a blood eosinophil count measurement available on the same day and with a one-year baseline and at least 6 weeks post index date. A dataset of unique patients from the Optimum Patient Care Research Database (OPCRD) will be used for analyses. Moreover, the Clinical Practice Research Datalink (CPRD) will be used to increase the number of available patients fitting the inclusion and exclusion criteria. The dataset from both the sources will be combined and duplicate records will be removed. A combined dataset of unique patients will be used for all the analyses. The study population will consist of patients with a COPD diagnostic Read code, with blood eosinophil counts recorded on an exacerbation date with no OCS and antibiotic use during the 2 weeks before the event and registered at general practices providing data to OPCRD (or CPRD) across the United Kingdom.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsOPRI Pte Ltd
Department/Research groupObservational and Pragmatic Research Institute Pte Ltd
Organisation/affiliationOPRI Pte Ltd
Website/Homepagewww.opri.sg
Details of (Primary) lead investigator
Title Professor
Last name Price
First name David
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)

Countries in which this study is being conducted
National study

United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed09/12/201609/12/2016
Start date of data collection27/12/201627/12/2016
Start date of data analysis06/01/201706/01/2017
Date of interim report, if expected
Date of final study report15/05/201824/04/2018
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesAstraZeneca100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name Price
First name David
Address line 15a Coles Lane
Address line 2Oakington 
Address line 3 
CityCambridge 
PostcodeCB24 3BA 
CountryUnited Kingdom
Phone number (incl. country code)440-1223967582 
Alternative phone number 
Fax number (incl. country code) 
Email address dprice@opri.sg
Public Enquiries
Title Professor 
Last name Price 
First name David 
Address line 15a Coles Lane 
Address line 2Oakington 
Address line 3 
CityCambridge 
PostcodeCB24 3BA 
CountryUnited Kingdom 
Phone number (incl. country code)440-1223967582 
Alternative phone number 
Fax number (incl. country code) 
Email address dprice@opri.sg 
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