1. Study identification
EU PAS Register NumberEUPAS26094
Official titleAn observational evaluation of the off-label prescribing and safety of glycopyrronium bromide for symptomatic treatment of severe sialorrhoea (drooling) and/or hyperhidrosis (excessive sweating)
Study title acronymGlycopyrronium Bromide
Study typeObservational study
Brief description of the studyThe proposed study will characterise real-world prescribing of GLY for the symptomatic treatment of severe sialorrhoea and/or excessive sweating. The study will then evaluate safety in patients prescribed GLY for sialorrhoea and/or excessive sweating compared to those not prescribed treatment. Data from this study will provide evidence towards a license evaluation for the use of GLY in the treatment of sialorrhoea and/or excessive sweating in adults in the UK.
Was this study requested by a regulator?Don't know
Is the study required by a Risk Management Plan (RMP)?
Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Department/Research groupObservational and Pragmatic Research Institute Pte Ltd
Organisation/affiliationOPRI Pte Ltd
Details of (Primary) lead investigator
Title Professor
Last name Price
First name David
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
National study
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed20/08/201820/08/2018
Start date of data collection17/09/201817/09/2018
Start date of data analysis
Date of interim report, if expected
Date of final study report30/11/201829/10/2018
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesMorningside Healthcare100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name Price
First name David
Address line 160 Paya Lebar Road,
Address line 2Paya Lebar Square
Address line 3Singapore
City409051
PostcodeSingapore
CountrySingapore
Phone number (incl. country code)4401223967582
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Professor
Last name Price
First name David
Address line 15a Coles Lane
Address line 2Oakington
Address line 3
CityCambridge
PostcodeCB24 3BA
CountryUnited Kingdom
Phone number (incl. country code)4401223967582
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Not applicable (disease/epidemiology study)
7. Medical conditions to be studied
Medical condition(s)No
8. Population under study
Age
Adults (18 - 44 years)
Adults (45 - 64 years)
Adults (65 - 74 years)
Adults (75 years and over)
Sex
Male
Female
9. Number of subjects
Estimated total number of subjects3500
10. Source of data
Is this study being carried out with an established data source?No
Sources of data
Routine primary care electronic patient registry
11. Scope of the study
What is the scope of the study?
Disease epidemiology
Primary scope : Disease epidemiology
12. Main objective(s)
What is the main objective of the study?
To quantify off-label prescribing of GLY for the symptomatic treatment of sialorrhoea
(drooling) and/or excessive sweating.
To evaluate adverse events (AE) in patients prescribed GLY for the symptomatic
treatment of sialorrhoea (drooling) and/or excessive sweating compared to those not
prescribed treatment.
Are there primary outcomes?No
Are there secondary outcomes?No
13. Study design
What is the design of the study?
Cohort study
14. Follow-up of patients
Will patients be followed up?Not applicable/no follow-up
15. Data analysis plan
Please provide a brief summary of the analysis method
The Chi-squared test or the Fisher’s exact test will be used to compare adverse events between the two groups. The total number of AEs will be computed along with the treatment duration, and the incidence rates will be calculated for the two groups and compared.
The Poisson regression model would be used to compare the rate of all AE events for the
GLY group as compared to the controls.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
Not submitted
18. Study Results
Not submitted
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documentsNot
submitted
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted