Status: Finalised
First registered on:
15/12/2015
Last updated on:
26/02/2019
1. Study identification
EU PAS Register NumberEUPAS11841
Official titleA cohort study to investigate the prescribing of albiglutide among women of child-bearing age who have type 2 diabetes
Study title acronym201795
Study typeObservational study
Brief description of the studyWith the cancellation of the Eperzan EU MA in January 2019, this post marketing study is no longer required or feasible to conduct. This is a cohort study using the UK Clinical Practice Research Datalink, CPRD, a national primary care database. A cohort of women aged 11 to 49 years with type 2 diabetes will be followed; a sub-group of women who have a pregnancy during the study period will also be identified. The objectives of this study are to: 1) assess the proportion and characteristics of women with type 2 diabetes of child-bearing age who are prescribed albiglutide, 2) assess the proportion and characteristics of women with type 2 diabetes who are prescribed albiglutide during pregnancy, 3) summarise outcomes of women prescribed albiglutide during pregnancy including reported major congenital malformations, pregnancy losses, stillbirths and neonatal deaths.
Was this study requested by a regulator?Yes: EMA
Is the study required by a Risk Management Plan (RMP)?
EU RMP category 3 (required)
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Department/Research groupPharmacy & Pharmacology
Organisation/affiliationUniversity of Bath
Details of (Primary) lead investigator
Title Professor
Last name GSK Clinical Disclosure Advisor
First name GSK Clinical Disclosure Advisor
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
National study
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed18/04/201517/11/2015
Start date of data collection01/01/201517/11/2015
Start date of data analysis
Date of interim report, if expected
Date of final study report21/09/202010/01/2019
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesGlaxoSmithKline100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name GSK Clinical Disclosure Advisor
First name GSK Clinical Disclosure Advisor
Address line 1980 Great West Road
Address line 2
Address line 3
CityBrentford
PostcodeTW8 9GS
CountryUnited Kingdom
Phone number (incl. country code)44-2080-475000
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Professor
Last name GSK Clinical Disclosure Advisor
First name GSK Clinical Disclosure Advisor
Address line 1980 Great West Road
Address line 2
Address line 3
CityBrentford
PostcodeTW8 9GS
CountryUnited Kingdom
Phone number (incl. country code)44-2080-475000
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Substance class (ATC Code)A10 (DRUGS USED IN DIABETES)
Single-Constituent (Substance INN)ALBIGLUTIDE
Product NameEperzan
CountryUnited Kingdom
Substance INN(s)ALBIGLUTIDE
Product NameTanzeum
CountryUnited States
Substance INN(s)ALBIGLUTIDE
7. Medical conditions to be studied
Medical condition(s)Yes
Type 2 diabetes mellitus
8. Population under study
Age
Infants and toddlers (28 days - 23 months)
Adolescents (12 - 17 years)
Adults (18 - 44 years)
Adults (45 - 64 years)
Sex
Female
Other population
Pregnant women
9. Number of subjects
Estimated total number of subjects10000
10. Source of data
Is this study being carried out with an established data source?Yes
Data sources registered with ENCePP
Sources of data
Routine primary care electronic patient registry
11. Scope of the study
What is the scope of the study?
Drug utilisation study
Primary scope : Drug utilisation study
12. Main objective(s)
What is the main objective of the study?
The primary objectives of the study are to: 1) assess the proportion and characteristics of women with type 2 diabetes of child-bearing age who are prescribed albiglutide and 2) assess the proportion and characteristics of women with type 2 diabetes who are prescribed albiglutide during pregnancy.
Are there primary outcomes?No
Are there secondary outcomes?Yes
Surveillance in pregnant women of major congenital malformations, pregnancy losses, stillbirths and neonatal deaths.
13. Study design
What is the design of the study?
Cohort study
Drug utilisation study
14. Follow-up of patients
Will patients be followed up?Yes
Please describe duration of follow up
Women will remain in the cohort (retrospective follow-up in the database) until they are aged 49 years or the study ends or the patient’s record ends, whichever comes first.
15. Data analysis plan
Please provide a brief summary of the analysis method
Characteristics of women in the cohort will be described by counts and proportions of the total women in the cohort. Incidence, period prevalence and days exposed to different medications will be calculated. Women who have a pregnancy during the study period will be identified. Patient characteristics at the start date of the pregnancy and prescribing received in the three months before the pregnancy start date and each trimester of pregnancy will be tabulated as counts and percentages. Patients receiving each class of medication will be described by three month period and outcome. Comparisons will be made between the albiglutide group and those receiving other medications, if sample sizes allow. Outcomes of pregnant women will be described by counts and proportions. Foetal outcomes will be compared (where numbers permit) between the different treatment combinations received by mothers during and/or in the three months before pregnancy and those whose mothers only received metformin.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
18. Study Results
Not submitted
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documents
DescriptionDocumentLatest version
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted
