Status: Finalised
First registered on:
09/02/2019
Last updated on:
13/06/2019
1. Study identification
EU PAS Register NumberEUPAS27963
Official titleSevere hypersensitivity reactions associated with iv iron containing medicinal products in countries of the European Economic Area – before and after implementation of risk minimisation measures
Study title acronym
Study typeOther: This is a pharmacoepidemiologic study with case-population design.
Brief description of the studyEvaluation of the reported rate of severe hypersensitivity reactions after administration of iv irons with respect to overall exposure in countries of the European Economic Area by using information from existing data sources
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)?
Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsIQVIA
Department/Research groupReal World Evidence Solutions
Organisation/affiliationIQVIA
Details of (Primary) lead investigator
Title Dr
Last name Annegret
First name Gohlke
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
International study
Austria
Belgium
Bulgaria
Croatia
Czech Republic
Denmark
Estonia
Finland
France
Germany
Greece
Hungary
Iceland
Ireland
Italy
Latvia
Lithuania
Netherlands
Norway
Poland
Portugal
Romania
Slovakia
Spain
Sweden
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed06/11/2018
Start date of data collection26/11/201826/11/2018
Start date of data analysis07/12/201817/12/2018
Date of interim report, if expected
Date of final study report15/02/201919/02/2019
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesVifor International AG100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Mrs
Last name Ehlken
First name Birgit
Address line 1Landshuter Allee 10
Address line 2
Address line 3
CityMuenchen
Postcode80637
CountryGermany
Phone number (incl. country code)49-89-4579126400
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Mrs
Last name Ehlken
First name Birgit
Address line 1Landshuter Allee 10
Address line 2
Address line 3
CityMuenchen
Postcode80637
CountryGermany
Phone number (incl. country code)49-89-4579126400
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Substance class (ATC Code)B03AC (Iron, parenteral preparations)
7. Medical conditions to be studied
Medical condition(s)Yes
Anaphylactoid shock
Anaphylactoid shock
Anaphylactic reaction
Anaphylactoid reaction
8. Population under study
Age
Children (2 - 11 years)
Adolescents (12 - 17 years)
Adults (18 - 44 years)
Adults (45 - 64 years)
Adults (65 - 74 years)
Adults (75 years and over)
Sex
Male
Female
9. Number of subjects
Estimated total number of subjects99999999
Additional information
not applicable
10. Source of data
Is this study being carried out with an established data source?Yes
Data sources registered with ENCePP
Data sources not registered with ENCePP
IQVIA MIDAS, United Kingdom
Sources of data
Sales data for drugs in European countries
11. Scope of the study
What is the scope of the study?
case-population study
Primary scope : case-population study
12. Main objective(s)
What is the main objective of the study?
To evaluate the overall and substance-specific reporting rate of anaphylactic/anaphylactoid reactions associated with i.v. iron-containing substances with respect to overall exposure of each i.v. iron substance in EEA countries for the 4-year period preceding the implementation of risk minimization measures (2010-2013) and the 4-year period after the implementation (2014-2017)
Are there primary outcomes?No
Are there secondary outcomes?No
13. Study design
What is the design of the study?
This is a pharmacoepidemiologic study with case-population design using established data sources.
14. Follow-up of patients
Will patients be followed up?Not applicable/no follow-up
15. Data analysis plan
Please provide a brief summary of the analysis method
In a descriptive analysis reporting rates of severe hypersensitivity reactions defined as anaphylactic reaction, anaphylactic shock, anaphylactoid reaction and anaphylactoid shock will be determined by number of reports divided by the number of 100 mg dose equivalents (DEq; =DDD) of iron sold.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
Not submitted
18. Study Results
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documentsNot
submitted
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted
