Status: Ongoing
First registered on:
26/04/2017
Last updated on:
05/05/2020
1. Study identification
EU PAS Register NumberEUPAS18739
Official titleDrug utilisation study of Intuniv® (guanfacine extended release) in European Countries – A prescriber survey
Study title acronymIntuniv survey study Europe
Study typeObservational study
Brief description of the studyThis is a multinational, cross-sectional, non-interventional and anonymous survey to assess drug utilisation of Intuniv which is indicated for treatment of attention deficit hyperactivity disorder. The survey will be carried out among physicians who will be asked to provide de-identified patient data. The survey will be conducted through a web-questionnaire among prescribers of Intuniv® in five European countries (Belgium, Finland, Ireland, Netherlands and Switzerland). In other countries utilization of Intuniv will be assessed in a database analysis which is described in a separate protocol.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)?
EU RMP category 3 (required)
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsIMS Health
Department/Research groupIQVIA Real World Insights
Organisation/affiliationIMS Health
Details of (Primary) lead investigator
Title Dr
Last name von Bredow
First name Dorothea
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
International study
Belgium
Finland
Ireland
Netherlands
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed30/08/201630/08/2016
Start date of data collection01/02/201920/02/2019
Start date of data analysis
Date of interim report, if expected30/06/201911/06/2019
Date of final study report30/06/2022
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesTakeda Pharmaceutical Company Limited100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Dr
Last name Page
First name Matthew
Address line 1Takeda Pharmaceutical Company Limited
Address line 2650 E. Kendall Street
Address line 3
CityCambridge
PostcodeMA 02142
CountryUnited States
Phone number (incl. country code)1-617-5843570
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Dr
Last name Page
First name Matthew
Address line 1Takeda Pharmaceutical Company Limited
Address line 2650 E. Kendall Street
Address line 3
CityCambridge
PostcodeMA 02142
CountryUnited States
Phone number (incl. country code)1-617-5843570
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Product NameIntuniv
CountryBelgium
Substance INN(s)GUANFACINE
Product NameIntuniv
CountryFinland
Substance INN(s)GUANFACINE
Product NameIntuniv
CountryIreland
Substance INN(s)GUANFACINE
Product NameIntuniv
CountryNetherlands
Substance INN(s)GUANFACINE
7. Medical conditions to be studied
Medical condition(s)Yes
Attention deficit/hyperactivity disorder
8. Population under study
Age
Infants and toddlers (28 days - 23 months)
Children (2 - 11 years)
Adolescents (12 - 17 years)
Adults (18 - 44 years)
Adults (45 - 64 years)
Adults (65 - 74 years)
Adults (75 years and over)
Sex
Male
Female
9. Number of subjects
Estimated total number of subjects1000
Additional information
The patient number is an estimate over 4 years, with data from 50 to 100 patients per country, who have been prescribed Intuniv® at least once during the reported (annual) study period.
10. Source of data
Is this study being carried out with an established data source?No
Sources of data
Data will be collected within a survey conducted among a representative sample of physicians known to treat patients with ADHD.
The survey will collect data from the following sources:
• physicians files (OneKey lists)
• information collected by a web questionnaire, including de-identified patient data.
11. Scope of the study
What is the scope of the study?
Drug utilisation study
Primary scope : Drug utilisation study
12. Main objective(s)
What is the main objective of the study?
Overall:
Drug utilization study with Intuniv® in European countries until 2021. Results will be reported annually.
Study objectives:
1.characterize patients, focussing on indications other than ADHD, children <6 years, adults
2. describe prescribing patterns of Intuniv® among physicians
3. assess compliance with indication, visits and measurements needed during the first year
of treatment
Are there primary outcomes?No
Are there secondary outcomes?No
13. Study design
What is the design of the study?
Drug utilisation study
14. Follow-up of patients
Will patients be followed up?Not applicable/no follow-up
15. Data analysis plan
Please provide a brief summary of the analysis method
Data analysis will be done descriptively as specified in the statistical analysis plan.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
Not submitted
18. Study Results
Not submitted
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documentsNot
submitted
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted
