Status: Finalised
First registered on:
23/10/2014
Last updated on:
17/11/2020
1. Study identification
EU PAS Register NumberEUPAS7761
Official titleWWE117397: Post-authorization safety Electronic Medical Records database retrospective cohort study of new users of inhaled UMEC/VI or new users of inhaled UMEC in the primary care setting: UK EMR distributed network study
Study title acronym
Study typeObservational study
Brief description of the studyThis study primarily aims to collect data reflecting the real-world experience with UMEC/VI and UMEC in the post-approval setting (period of up to 24 months from the start of UMEC/VI and UMEC availability in the United Kingdom).
The study will use a retrospective longitudinal non-interventional observational study design to identify patients based on a new prescription (index prescription date) for UMEC/VI, UMEC, or other long acting bronchodilators (LABD). These patients will be followed-up from their index prescription date until censoring at death, leaving practice, or end of follow-up at 30 June 2017.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)?
Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsCPRD
Department/Research group
Organisation/affiliationClinical Practice Research Datalink
Details of (Primary) lead investigator
Title Mr
Last name Dedman
First name Daniel
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
National study
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed04/06/201404/06/2014
Start date of data collection01/03/201501/03/2015
Start date of data analysis
Date of interim report, if expected31/03/2017
Date of final study report31/12/201910/12/2019
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesGlaxoSmithKline100
Charities
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Mr
Last name Dedman
First name Daniel
Address line 1151 Buckingham Palace Road
Address line 2
Address line 3
CityLondon
PostcodeSW1W 9SZ
CountryUnited Kingdom
Phone number (incl. country code)44-203-0806383
Alternative phone number
Fax number (incl. country code)44-203-1189802
Public Enquiries
Title Mr
Last name Dedman
First name Daniel
Address line 1151 Buckingham Palace Road
Address line 2
Address line 3
CityLondon
PostcodeSW1W 9SZ
CountryUnited Kingdom
Phone number (incl. country code)44-203-0806383
Alternative phone number
Fax number (incl. country code)44-203-1189802
6. Study drug(s) information
Product NameIncruse/Laventair
CountryUnited Kingdom
Substance INN(s)UMECLIDINIUM BROMIDE
Product NameAnoro
CountryUnited Kingdom
Substance INN(s)UMECLIDINIUM BROMIDE
VILANTEROL TRIFENATATE
7. Medical conditions to be studied
Medical condition(s)Yes
Chronic obstructive pulmonary disease
8. Population under study
Age
Children (2 - 11 years)
Adolescents (12 - 17 years)
Adults (18 - 44 years)
Adults (45 - 64 years)
Adults (65 - 74 years)
Adults (75 years and over)
Sex
Male
Female
9. Number of subjects
Estimated total number of subjects2000
Additional information
At least 1,000 new users of umeclidinium/vilanterol (UMEC/VI) and 1,000 new users of umeclidinium (UMEC).
10. Source of data
Is this study being carried out with an established data source?Yes
Data sources registered with ENCePP
Sources of data
Administrative database, e.g. claims database
Routine primary care electronic patient registry
11. Scope of the study
What is the scope of the study?
Risk assessment
Drug utilisation study
Primary scope : Drug utilisation study
12. Main objective(s)
What is the main objective of the study?
This study primarily aims to collect data reflecting the ‘real-world’ experience with umeclidinium/vilanterol (UMEC/VI) and umeclidinium (UMEC) in the post-approval setting. UMEC/VI and UMEC as well as other medications containing only long-acting bronchodilators (LABD) are indicated for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
Are there primary outcomes?Yes
Off-label use, defined as prescribing in patients without a recorded diagnosis of COPD.
Are there secondary outcomes?Yes
1. The frequency of Myocardial infarction, Heart failure, Stroke, Pneumonia, Death, COPD exacerbations
2. Treatment patterns (discontinuation, switch or augmentation) and medication adherence (Medication Possession Ratio (MPR) and Proportion of Days Covered (PDC)
13. Study design
What is the design of the study?
Drug utilisation study
14. Follow-up of patients
Will patients be followed up?Yes
Please describe duration of follow up
Patients will be followed-up from their index prescription date until censoring at death, leaving practice, or end of follow-up on 30 June 2017.
15. Data analysis plan
Please provide a brief summary of the analysis method
Primary Outcome:
Among new users of UMEC/VI, UMEC, or other LABD, calculate the proportion with off label use according to presence or absence of a COPD diagnosis record.
Secondary Outcomes:
Among new users of UMEC/VI or UMEC, calculate the incidence (new events/person-time) of myocardial infarction, heart failure, stroke, death, pneumonia/lower respiratory tract infections, and exacerbations of COPD.
Among new users UMEC/VI or UMEC, describe treatment patterns (discontinuation, switching and augmentation) and adherence to treatment using medication possession ratio proportion of days covered during the 0-12 months of follow-up.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
Yes
17. Full protocol
18. Study Results
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Other documents
DescriptionDocumentLatest version
