Last updated on: 03/04/2014
Name of organisation
1) Department/Research groupPharmacoepidemiology research team
2) Organisation/affiliationUniversity of Toulouse 3 and INSERM 1027
Short Name in the inventoryPharmacoepidemiology INSERM 1027
Administrative Contact
Title Dr
Last name Lapeyre-Mestre
First name Maryse
Address line 137 Allees Jules Guesde
Address line 2
Address line 3
CityToulouse
Postcode31000
CountryFrance
Phone number (incl. country code)33-561145960
Alternative phone number33-561145606
Fax number (incl. country code)33-561145928
Scientific Contact
Title Dr
Last name Lapeyre-Mestre
First name Maryse
Address line 137 Allees Jules
Address line 2
Address line 3
CityToulouse
Postcode31000
CountryFrance
Phone number (incl. country code)33-561145960
Alternative phone number33-561145606
Fax number (incl. country code)33-561145928
2. Description
The research team of pharmacoepidemiology is one of the 6 research teams of the INSERM Unit “Epidemiology and Public Health Analysis: Risks, chronic illnesses and disabilities". This team consists of academic researchers involved in the field of clinical pharmacology, internal medicine and general medicine. The research activity focuses on analysing drug-related risk from different data sources (spontaneous reporting system, health insurance and hospital medical data). The main topics concern drug exposure in pregnancy, drug abuse and pharmacovigilance
3. Category
University based
Hospital based
4. Available resources
In houseVia Contacts/Network
5. Therapeutic/disease areas of research in drug safety/risk-benefit performed in the past 5 years
Anaesthesia
Congenital Malformations
Disorders of the central nervous system
Geriatrics
Immunological products and vaccines
Infectious diseases
Liver disease
Musculoskeletal and joint diseases
Neonates
Pregnancy
addiction
6. Design of drug safety/risk-benefit studies published in the past 5 years
Cohort Study
Case Control Study
Drug Utilisation
7. Experience in collecting data directly from individual patients/respondents
None
8. Access to data collection resources
Capacity to conduct face-to-face interviews
Yes
In a clinic
Yes
In the community
Yes
Electronic data capture systems
Yes
System used:
Health insurance system
Interactive voice response systems
No
Call centre
No
9. Experience in secondary research and meta-analysis
Yes
10. Work with existing data resources in the past 3 years
Name of data resourceNo. of studies
CPRD2
French PV database10
Hospital Discharge5
SNIIRAM (French Insurance System)10
Echantillon Généraliste des Bénéficiaires (EGB) France4
11. Registries established by centre
Other Drug in pregnancy (EFEMERIS)
12. Experience in collaboration in a study team
Principal Investigator
Collaborating Investigator
13. Current involvement in research networks
None
14. Interest in research opportunities which are funded
By charities
By government
15. Interest in contract research only if free to publish results
Yes
16. Selected publications of the last 5 calendar years
ReferenceLink to web-publication
Gallini A, Andrieu S, Donohue JM, Oumouhou N, Lapeyre-Mestre M, Gardette V.
Trends in use of antipsychotics in elderly patients with dementia: Impact of national safety warnings.Eur Neuropsychopharmacol. 2014 Jan;24(1):95-104. doi: 10.1016/j.euroneuro.2013.09.003. Epub 2013 Sep 17.
http://dx.doi.org/10.1016/j.euroneuro.2013.09.003
Gardette V, Lapeyre-Mestre M, Piau A, Gallini A, Cantet C, Montastruc JL, Vellas B, Andrieu S; ICTUS Group.
A 2-Year Prospective Cohort Study of Antidementia Drug Non-Persistency in Mild-to-Moderate Alzheimer's Disease in Europe : Predictors of Discontinuation and Switch in the ICTUS Study.CNS Drugs. 2014 Feb;28(2):157-70. doi: 10.1007/s40263-013-0133-3.
http://link.springer.com/article/10.1007%2Fs40263-013-0133-3
Moulis G, Sailler L, Sommet A, Lapeyre-Mestre M, Derumeaux H, Adoue D.
Rituximab versus splenectomy in persistent or chronic adult primary immune thrombocytopenia: an adjusted comparison of mortality and morbidity.Am J Hematol. 2014 Jan;89(1):41-6. doi: 10.1002/ajh.23580. Epub 2013 Sep 30.
http://onlinelibrary.wiley.com/doi/10.1002/ajh.23580/full
de Souto Barreto P, Lapeyre-Mestre M, Vellas B, Rolland Y.Potential underuse of analgesics for recognized pain in nursing home residents with dementia: a cross-sectional study. Pain. 2013 Nov;154(11):2427-31. doi: 10.1016/j.pain.2013.07.017. Epub 2013 Jul 18.http://dx.doi.org/10.1016/j.pain.2013.07.017
Durrieu G, Palmaro A, Pourcel L, Caillet C, Faucher A, Jacquet A, Ouaret S, Perault-Pochat MC, Kreft-Jais C, Castot A, Lapeyre-Mestre M, Montastruc JL; French Network of Pharmacovigilance Centres.First French experience of ADR reporting by patients after a mass immunization campaign with Influenza A (H1N1) pandemic vaccines: a comparison of reports submitted by patients and healthcare professionals. Drug Saf. 2012 Oct 1;35(10):845-54. doi: 10.2165/11631800-000000000-00000.
