Status: Finalised
First registered on:
24/11/2014
Last updated on:
24/11/2014
1. Study identification
EU PAS Register NumberEUPAS8019
Official titleCharacterising patients at risk of failed Diskus use in primary care
Study title acronym
Study typeObservational study
Brief description of the studyThe aim of this study is to identify patient characteristics in a large sample of primary care patients that use a Diskus inhaler. The prevalence and factors associated with inhaler misuse will be investigated. In addition we aim to assess the relationship between inhalation technique and clinical outcomes. These results should assist physicians in evaluating the potential impact of the type of device prescribed to a patient.
This study will answer the following questions:
• Which serious errors in Diskus inhaler technique are most frequently made?
• Are certain patient characteristics linked to incorrect inhaler technique for Diskus?
• Are patient reported outcomes linked to incorrect inhaler technique for Diskus?
• Does incorrect inhaler technique correlate to asthma risk assessment?
In addition, the type and frequency of serious errors being performed when using Diskus will be analysed to better characterise patient errors and identify ways in which inhaler technique may be improved.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)?
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsRIRL
Department/Research group
Organisation/affiliationResearch in Real Life Ltd.
Details of (Primary) lead investigator
Title Dr
Last name Davis
First name Emily
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)
Countries in which this study is being conducted
International study
Australia
France
Italy
Netherlands
Norway
Spain
Sweden
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed03/09/201303/09/2013
Start date of data collection01/06/201101/06/2011
Start date of data analysis10/10/201314/10/2013
Date of interim report, if expected10/01/201410/01/2014
Date of final study report19/03/201424/11/2014
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companiesTeva50
Charities
Government body
Research councils
EU funding scheme
OtherRiRL50
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name Price
First name David
Address line 116 Raffles Quay
Address line 2#33-03
Address line 3Hong Leong Building
CitySingapore
Postcode048581
CountrySingapore
Phone number (incl. country code)44-1223967829
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Professor
Last name Price
First name David
Address line 116 Raffles Quay
Address line 2#33-03
Address line 3Hong Leong Building
CitySingapore
Postcode048581
CountrySingapore
Phone number (incl. country code)44-1223967829
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Not applicable (disease/epidemiology study)
7. Medical conditions to be studied
Medical condition(s)Yes
Asthma
8. Population under study
Age
Adults (18 - 44 years)
Adults (45 - 64 years)
Adults (65 - 74 years)
Adults (75 years and over)
Sex
Male
Female
9. Number of subjects
Estimated total number of subjects623
10. Source of data
Is this study being carried out with an established data source?Yes
Data sources not registered with ENCePP
Optimum Patient Care (OPC), United Kingdom
Spanish Primary Care Respiratory Group GP network (GRAP)., Spain
Woolcock Institue of Medical Research, Australia
Lunger i Praksis, Norway
Universitair Medisch Centrum Gronigen (UMCG), Netherlands
Sources of data
Routine primary care electronic patient registry
11. Scope of the study
What is the scope of the study?
Device utilisation study
Primary scope : Device utilisation study
12. Main objective(s)
What is the main objective of the study?
1. Define the serious errors commonly performed by patients with asthma using Diskus
2. Characterise patients who perform serious errors using Diskus and those that do not
3. Examine patient reported outcomes with Diskus usage
The above objectives will enable the relationship between inhalation technique and clinical outcomes to be investigated.
Are there primary outcomes?No
Are there secondary outcomes?No
13. Study design
What is the design of the study?
Cohort study
14. Follow-up of patients
Will patients be followed up?Not applicable/no follow-up
15. Data analysis plan
Please provide a brief summary of the analysis method
Patients will be separated into two groups: those performing serious error(s) and those not. Patient demographics and clinical characteristics analysed as follows:
Summary statistics were produced for all variables, as a complete dataset and by error categories analysed. Statistically significant results will be defined as p<0.05 and trends as 0.05≤p<0.10.
Univariable logistic regression models, with a dichotomous indicator variable for serious errors made (yes/no) as the dependent variable and each patient characteristic as an explanatory variable, were first used to identify characteristics associated with making serious errors. Demographic and clinical characteristics associated with making ≥1 serious errors in the univariable model (P<0.05) were entered into a multivariable model, which was stepwise reduced to produce a final list of non-collinear independently associated variables.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
18. Study Results
Not submitted
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
None
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documentsNot
submitted
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted
