Study Comparing Risk of Hospitalization for Heart Failure Between Dipeptidyl Peptidase-4 Inhibitors and Sulfonylureas

Primary objective: To compare the risk of hospitalization for heart failure (hHF) between patients with type 2 diabetes mellitus (T2DM) treated with dipeptidyl peptidase-4 inhibitors (DPP-4is) vs. sulfonylureas (SUs)Secondary objectives:1. To compare the risk of hospitalization for acute myocardial infarction (AMI), hospitalization for stroke, hospitalization for unstable angina, coronary revascularization, and a composite of all aforementioned outcomes including hHF between patients with T2DM treated with DPP-4is vs. SUs2. To compare the risk of hHF between patients with T2DM treated with saxagliptin vs. sitagliptin or linagliptin 3. To compare the risk of hospitalization for AMI, hospitalization for stroke, hospitalization for unstable angina, coronary revascularization, and a composite of all aforementioned outcomes including hHF between patients with T2DM treated with saxagliptin vs. sitagliptin or linagliptinStudy designThis will be a retrospective, observational cohort study. This study will use as its methodological foundation, as closely as possible and appropriate, the approach that is outlined in the Mini-Sentinel protocol for active surveillance of AMI in association with use of anti-diabetic agents.