Status: Ongoing First registered on: 04/04/2018
Last updated on: 04/04/2018
1. Study identification
EU PAS Register NumberEUPAS23454
Official titleLongitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in 2 million people over 2 decades
Study title acronymBMI and Parkinson´s disease
Study typeObservational study
Brief description of the studyPrevious research suggests that people who are overweight or obese may have a higher risk of developing Parkinson’s disease than people with normal weight, while other studies show no such association. The objective of this study is therefore to investigate the association between BMI and risk of Parkinson’s disease. A cohort will be derived from CPRD of people aged 40 years or older with a first BMI recording between 1992 and 2007. People with a prior record of Parkinson’s disease or dementia will be excluded. Incidence rates of Parkinson’s disease will be calculated for each BMI category using Poisson regression, adjusting for differences in patient characteristics and allowing for competing risks with a novel approach. This study will provide information from a very large number of people (2 million) with a sizeable amount of follow-up data in a representative sample. The findings will therefore provide important information to help clarify the relationship between BMI and Parkinson’s disease to inform preventative and therapeutic strategies for Parkinson’s disease.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsOXON
Department/Research groupOXON Epidemiology
Organisation/affiliationOXON Epidemiology Ltd.
Website/Homepagewww.oxonepi.com
Details of (Primary) lead investigator
Title Dr
Last name Qizilbash MBChB MRCP(UK) BSc MSc DPhil(Oxon.)
First name Nawab
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Multiple centres

In total how many centres are involved in this Study?2

Countries in which this study is being conducted
International study

Spain
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed20/07/201620/07/2016
Start date of data collection20/07/201620/07/2016
Start date of data analysis15/09/201615/09/2016
Date of interim report, if expected
Date of final study report17/09/2018
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
Charities
Government body
Research councils
EU funding scheme
OtherNo funding100
5. Contact details for enquiries
Scientific Enquiries
Title Dr
Last name Qizilbash MBChB MRCP(UK) BSc MSc DPhil(Oxon.)
First name Nawab
Address line 1Calle Dr. Fleming 51
Address line 2 
Address line 3 
CityMadrid 
Postcode28036 
CountrySpain
Phone number (incl. country code)34-913459395 
Alternative phone number34-629846059 
Fax number (incl. country code)34-913459394 
Email address n.qizilbash@oxonepi.com
Public Enquiries
Title Professor 
Last name Pocock 
First name Stuart 
Address line 1London School of Hygiene & Tropical Medicine 
Address line 2Keppel Street 
Address line 3 
CityLondon 
PostcodeWC1E 7HT 
CountryUnited Kingdom 
Phone number (incl. country code)442076368636 
Alternative phone number 
Fax number (incl. country code)442076372853 
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