Status: Planned First registered on: 12/05/2018
Last updated on: 30/04/2021
1. Study identification
EU PAS Register NumberEUPAS23959
Official titleLongitudinal Analyses of Blood Lipids and Future Risk of Dementia in CPRD
Study title acronymLipids and dementia
Study typeObservational study
Brief description of the studyEstablishing modifiable risk factors of dementia risk is a global priority. The relationship of lipids to the risk of developing dementia is unclear. Previous research based on small studies suggests that people who have high cholesterol in midlife may have an increased risk of developing dementia some 20 years later. The proposed study will use information from a large number of people in the UK to investigate the relationship between lipids (total cholesterol, LDL and HDL) and the future risk of developing dementia. People aged 40 years or older with a lipid reading between 1992 and 2009 will be selected from the CPRD primary care database. Their recorded development of dementia will be investigated, whilst accounting for differences in characteristics (e.g. age, gender, etc.). This study will provide information from a very large number of people with a sizeable amount of follow-up data which will be representative of the UK population. The findings will therefore provide important information to help clarify the relationship between lipids and dementia. The findings will help to inform preventative strategies for dementia.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsOXON
Department/Research groupOXON Epidemiology
Organisation/affiliationOXON Epidemiology Ltd.
Website/Homepagewww.oxonepi.com
Details of (Primary) lead investigator
Title Professor
Last name Qizilbash MBChB MRCP(UK) BSc MSc DPhil(Oxon.)
First name Nawab
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Multiple centres

In total how many centres are involved in this Study?2

Countries in which this study is being conducted
International study

Spain
United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed01/06/2016
Start date of data collection15/09/2016
Start date of data analysis
Date of interim report, if expected
Date of final study report31/05/2018
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
CharitiesAlzheimer´s Society100
Government body
Research councils
EU funding scheme
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name Qizilbash MBChB MRCP(UK) BSc MSc DPhil(Oxon.)
First name Nawab
Address line 1Calle Dr. Fleming 51
Address line 2 
Address line 3 
CityMadrid 
Postcode28036 
CountrySpain
Phone number (incl. country code)34-913459395 
Alternative phone number34-629846059 
Fax number (incl. country code)34-913459394 
Email address n.qizilbash@oxonepi.com
Public Enquiries
Title Professor 
Last name Pocock 
First name Stuart 
Address line 1London School of Hygiene & Tropical Medicine 
Address line 2Keppel Street 
Address line 3 
CityLondon 
PostcodeWC1E 7HT 
CountryUnited Kingdom 
Phone number (incl. country code)442076368636 
Alternative phone number 
Fax number (incl. country code)442076372853 
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