Last updated on: 05/06/2019
1. Contact details
This data source is maintained by the following centre registered in the ENCePP inventory of research centres: CPRD
Name of data sourceClinical Practice Research Datalink
Name under which the data source should be displayed in the inventory (e.g short name if one exists)CPRD
Name of organisation
1) Department/research group
2) Organisation/affiliationClinical Practice Research Datalink
Administrative Contact
Title Ms
Last name Au
First name Sherlin
Address line 110 South Colonnade, Canary Wharf
Address line 2
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
Scientific Contact
Title Ms
Last name Williams
First name Rachael
Address line 110 South Colonnade, Canary Wharf
Address line 2
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
Alternative Contact
Title Ms
Last name Jenny
First name Campbell
Address line 110 South Colonnade, Canary Wharf
Address line 2
Address line 3
CityLondon
PostcodeE14 4PU
CountryUnited Kingdom
2. Description/category
Routine primary care electronic patient registry
Linked databases
3.1 Coverage of licensed medicinal products
Licensed Medicinal Product
Comments
Community / general practice data
Available through GP prescribing.
OTC
Because of the NHS, use of OTC medications, as opposed to NHS prescribed medications, is a smaller issue than in most countries.
Vaccines
Most vaccines are given in primary care and are included in CPRD.
3.2 ATC code (5th level)
No
3.3 Other product dictionaries
Gemscript, DM+D
3.4 Recording of indication for use
Yes
Is a coding dictionary being used? READ, SNOMED
4. Coverage of events
Event
Dictionary
Dictionary details
Adverse events (for pharmacovigilance databases)
Yes
Recorded in patient records
Symptoms/signs
Yes
Coded at point of care
Diagnosis in primary care
Yes
Coded at point of care
Specialist diagnosis
No
Discharge diagnosis
No
Laboratory values
Yes
Coded via GP system
Death
Yes
Date and cause + linkage to death registration data
Procedures
Yes
From linked hospital records
Overdoses
Yes
Coded at point of care
Teratogenic events
Yes
Coded at point of care
Specific event
Description: The CPRD was set up as both a clinical and research data collection system based on the electronic health care records of the essentially paperless NHS.
Yes
Coded at point of care
5. Year of establishment
1988
6. Geographical origin of data
EEA/EFTA countries
United Kingdom
7. Demographical extent of data collection
Nation-wide
8. Age groups
17 years and under [Paediatrics]
preterm newborn infants
term newborn infants (0 to 27 days)
infants and toddlers (28 days to 23 months)
children (2 to 11 years)
adolescents (12 to 17 years)
18 to 45 years
46 to 64 years
65 years and over
65 to 75 years
76 years and over
9. Size of the source/catchment population
65,000,000
10 a. Total (cumulative) number of persons with actual data
35,000,000
10 b. Number of persons with active data collection in past calendar year
11,000,000
11. Possibility to obtain additional information on the patient
a) Clinical information from treating physician?
Yes
b) Questionnaire data from the patient?
Yes
c) Genetic information or samples?
Yes
12. Possibility of links to other sources of data
Yes :
The CPRD is set up to be able to link to any other NHS data source.
Currently it is linked to Hospital Episode Statistics (HES) (Admitted
Patient Care (APC), Outpatient (OP), Accident & Emergency (A&E),
Diagnostic Imaging Dataset (DID)), Office for National Statistics
(ONS) Death Registration data, Socioeconomic data (Townsend
Scores/Index of Multiple Deprivation-IMD/Carstairs/Rural-Urban Classification), National Cancer Registration and Analysis Service (NCRAS) (Cancer registration data,
Cancer Patient Experience Survey (CPES), Systemic Anti-Cancer
Treatment (SACT), National Radiotherapy Dataset (RtDS), Quality of Life of Cancer Survivors in England (QOLP), and Quality of Life of Colorectal Cancer Survivors in England (QOLC)), Mental Health Dataset (MHDS) and facilitates bespoke linkages.
13. Written policy governing data access
Yes
14. Committee to evaluate requests for data access
Yes
15. Charge/fee for data access
Yes
Special arrangements for academic purposes:
Yes
16. Selected publications of the last 5 calendar years using data from this data source
ReferenceLink to web-publication
Herrett E, Gallagher AM, Bhaskaran K, Forbes H,
Mathur R, van Staa T, Smeeth L. Data Resource
Profile: Clinical Practice Research Datalink (CPRD).
Int J Epidemiol. 2015 Jun;44(3):827-36.https://www.ncbi.nlm.nih.gov/pub med/26050254
van Staa TP et al. The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials. Health Technol Assess. 2014 Jul;18(43):1-146.https://www.ncbi.nlm.nih.gov/pubmed/25011568
Kousoulis AA, Rafi I, de Lusignan S. The CPRD and the RCGP: building on research success by enhancing benefits for patients and practices. Br J Gen Pract. 2015 Feb;65(631):54-5.http://bjgp.org/content/65/631/54
