Status: Planned First registered on: 28/11/2019
Last updated on: 28/11/2019
1. Study identification
EU PAS Register NumberEUPAS32482
Official titleExploring differences in asthma disease severity and pathways: variation by ethnicity and socioeconomic status
Study title acronym
Study typeObservational study
Brief description of the studyThis is a retrospective cohort study using data from English general practices registered with the OPCRD. The specific aims are to: • Explore differences in asthma severity, asthma control and asthma phenotype by ethnic and socioeconomic groups • Explore patterns of medication usage and healthcare utilisation (scheduled and unscheduled) for asthma in different ethnic and socioeconomic groups • To identify determinants of asthma severity in different ethnic and socioeconomic groups • Investigate disparities in referral patterns for patients from different ethnic and socioeconomic groups thnicity will be identified from GP ad/or HES records. Socioeconomic Status will be measured using Index of Multiple Deprivation. Asthma severity (assessed using medications), lung function, blood eosinophils, medication adherence, healthcare utilisation and specialist referral will be ascertained from GP records. Descriptive statistics will be calculated for the entire cohort and for each ethnic and socioeconomic group separately. Multivariable analysis accounting for differences in demographic and lifestyle factors (e.g. BMI, Smoking) will be conducted using appropriate regression models.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre nameQueens University Belfast
Centre locationBelfast, UK
Details of (Primary) lead investigator
Title Dr
Last name John
First name Busby
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)

Countries in which this study is being conducted
National study

United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed28/11/2019
Start date of data collection06/01/2020
Start date of data analysis
Date of interim report, if expected
Date of final study report01/07/2020
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
Charities
Government body
Research councils
EU funding scheme
OtherNo external funding100
5. Contact details for enquiries
Scientific Enquiries
Title Dr
Last name John
First name Busby
Address line 1Centre for Public Health
Address line 2Royal Victoria Hospital 
Address line 3 
CityBelfast 
Postcode 
CountryUnited Kingdom
Phone number (incl. country code)442890976019 
Alternative phone number 
Fax number (incl. country code) 
Email address john.busby@qub.ac.uk
Public Enquiries
Title Dr 
Last name John 
First name Busby 
Address line 1Centre for Public Health 
Address line 2Royal Victoria Hospital 
Address line 3 
CityBelfast 
Postcode 
CountryUnited Kingdom 
Phone number (incl. country code)442890976019 
Alternative phone number 
Fax number (incl. country code) 
Email address john.busby@qub.ac.uk 
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