Status: Ongoing
First registered on:
26/03/2021
Last updated on:
24/04/2023
1. Study identification
EU PAS Register NumberEUPAS39226
Official titleRegistry for pregnant women exposed to SARS-CoV-2 (COVID-19, CONSIGN study)
Study title acronymCOVI-PREG
Study typeObservational study
Brief description of the studyThe COVI-PREG registry aims to collect data to understand the natural history of the SARS-CoV-2 among pregnant women and the impact on maternal, pregnancy and neonatal outcomes. The COVI-PREG project is part of the Covid-19 infectiOn aNd medicineS In preGNancy (CONSIGN) project that study the impact of COVID-19 infection and medicines in pregnancy, as work package 3. The mains objectives are to describe, among positive SARS-CoV-2 pregnant women, the use of medicines, the impact of medicine use on COVID-19 severity and on pregnancy and neonatal outcome.
Was this study requested by a regulator?Yes: EMA
Is the study required by a Risk Management Plan (RMP)?
Non-EU RMP only
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicableTrial registration number: ID 2020-00548 – Swissethics (Swiss Association of Research Ethics Committee)
2. Research centres and Investigator details
Coordinating study entity
Centre nameLausanne University Hospital
Centre locationLausanne, Switzerland
Details of (Primary) lead investigator
Title Professor
Last name Panchaud
First name Alice
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Multiple centres
In total how many centres are involved in this Study?150
Countries in which this study is being conducted
International study
Argentina
Belgium
Brazil
Chile
Colombia
Egypt
France
French Guiana
Germany
Ireland
Israel
Italy
Mexico
Peru
Portugal
Spain
Switzerland
United Kingdom
United States
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed24/03/2020
Start date of data collection24/03/2020
Start date of data analysis
Date of interim report, if expected
Date of final study report31/07/2023
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
Charities
Government bodySwiss Public health office40
Research councils
EU funding schemeEMA40
OtherCHUV10
UNIBe10
5. Contact details for enquiries
Scientific Enquiries
Title Professor
Last name Panchaud
First name Alice
Address line 1Service of Pharmacy
Address line 2
Address line 3
CityLausanne
PostcodeCH-1011
CountrySwitzerland
Phone number (incl. country code)41795564973
Alternative phone number
Fax number (incl. country code)
Public Enquiries
Title Professor
Last name Panchaud
First name Alice
Address line 1Service of Pharmacy
Address line 2
Address line 3
CityLausanne
PostcodeCH-1011
CountrySwitzerland
Phone number (incl. country code)41795564973
Alternative phone number
Fax number (incl. country code)
6. Study drug(s) information
Not applicable (disease/epidemiology study)
7. Medical conditions to be studied
Medical condition(s)No
8. Population under study
Age
Preterm newborns
Term newborns (0-27 days)
Infants and toddlers (28 days - 23 months)
Adults (18 - 44 years)
Sex
Female
Other population
Pregnant women
9. Number of subjects
Estimated total number of subjects3000
10. Source of data
Is this study being carried out with an established data source?No
Sources of data
Exposure registry
11. Scope of the study
What is the scope of the study?
Disease epidemiology
Risk assessment
Drug utilisation study
Primary scope : Drug utilisation study
12. Main objective(s)
What is the main objective of the study?
i.To characterise the clinical course of SARS-CoV-2 infection during pregnancy
ii.To assess the risk assessment of vertical transmission and congenital lesions
iii.To quantify the risk of adverse maternal outcomes, pregnancy outcomes and neonatal outcomes
iv. To identify additional risk factors and risk modifiers
Are there primary outcomes?Yes
maternal, obstetrical and neonatal outcomes
Are there secondary outcomes?No
13. Study design
What is the design of the study?
Cohort study
14. Follow-up of patients
Will patients be followed up?Yes
Please describe duration of follow up
until the end of pregnancy and/or the 4 first postpartum weeks
15. Data analysis plan
Please provide a brief summary of the analysis method
It will be evaluated for each future research question by the Registry Scientific Advisory Committee and a biomedical research Ethics committee.
Interim analysis to get an early appraisal of study findings might be considered for some aims and will be submitted for approval to a biomedical research Ethics committee.
16. ENCePP seal
Are you requesting the ENCePP seal for this study?
No
17. Full protocol
Available when the study ends
18. Study Results
Not submitted
Please list the 5 most relevant publications using data from your study
ReferenceLink to web-publication
Favre G, Gerbier E, Maisonneuve E, Pomar L, Winterfeld U, Lepigeon K, Bloemenkamp KWM, de Bruin O, Eimir H, Nordeng H, Siiskonen SJ, Sturkenboom MCJM, Baud D, Panchaud A; COVI-PREG and CONSIGN group. COVID-19-related medicine utilization study in pregnancy: The COVI-PREG cohort. Br J Clin Pharmacol. 2023 May;89(5):1560-1574. doi: 10.1111/bcp.15611. Epub 2022 Dec 16. PMID: 36417423.https://doi.org/10.1111/bcp.15611
19. Other relevant documents
Conflict(s) of interest of
investigator(s)Not submitted
Composition of Steering Group and
ObserversNot submitted
Other documentsNot
submitted
Signed Code of
Conduct Checklist
Not submitted
Signed Code of Conduct Declaration
Not submitted
Signed Checklist for Study
Protocols
Not submitted
