Onset of asthma in severe asthma patients (PATH)

This study aim is to describe and compare the demographic and clinical features of early-onset vs late-onset asthma phenotypes in an international cohort of adult patients with severe asthma. The primary objectives are: ● To describe the distribution of age of asthma onset in the international severe asthma registry cohort ● To define and validate the most appropriate age cut-off to delineate age-of-onset groups ● To describe and compare the demographic and clinical characteristics of the early-onset vs late-onset asthma phenotypes in adult patients with severe asthma The secondary objective is to evaluate possible geographical differences in early-onset and late-onset asthma phenotypes in severe asthma population. Data will be sourced from the International Severe Asthma Registry (ISAR). Anonymized person-level data from 9 countries will be used for this analysis. ISAR has governance provided by the ISAR scientific steering committee, The Anonymous Data Ethics Protocols and Transparency (ADEPT) committee, an independent body of experts and regulators commissioned by the Respiratory Effectiveness Group (REG).