Status: Planned First registered on: 10/01/2022
Last updated on: 20/10/2022
1. Study identification
EU PAS Register NumberEUPAS45073
Official titleComparative Effectiveness and Safety of Direct Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation in the UK
Study title acronym
Study typeObservational study
Brief description of the studyThis study aims to evaluate the incidence of stroke and other outcomes in association with direct oral anticoagulants (DOACs) as compared to each other (i.e., direct comparisons) among patients with nonvalvular atrial fibrillation (AFib) in the UK. Individual DOACs of interest include apixaban, rivaroxaban, edoxaban, and dabigatran.
Was this study requested by a regulator?No
Is the study required by a Risk Management Plan (RMP)? Not applicable
Regulatory procedure number (RMP Category 1 and 2 studies only)
Other study registration identification numbers and URLs as applicable
2. Research centres and Investigator details
Coordinating study entity
Centre to which the investigator belongsAetion
Department/Research group
Organisation/affiliationAetion
Website/Homepagewww.aetion.com
Details of (Primary) lead investigator
Title Dr
Last name Ali
First name Ayad
Is this study being carried out with the collaboration of a research network?
No
Other centres where this study is being conducted
Not applicable (single centre)

Countries in which this study is being conducted
National study

United Kingdom
3. Study timelines: initial administrative steps, progress reports and final report
PlannedActual
Date when funding contract was signed08/06/2021
Start date of data collection01/09/2021
Start date of data analysis
Date of interim report, if expected
Date of final study report28/02/2022
4. Sources of funding
Please provide estimates of the percentage of funding by source for this study
Names(s)Approximate % funding
Pharmaceutical companies
Charities
Government body
Research councils
EU funding scheme
OtherAetion100
5. Contact details for enquiries
Scientific Enquiries
Title Ms
Last name Amanda
First name Patrick
Address line 15 Penn Plaza
Address line 27th Floor 
Address line 3 
CityNew York 
Postcode10001 
CountryUnited States
Phone number (incl. country code)018448238466 
Alternative phone number 
Fax number (incl. country code) 
Email address amanda.patrick@aetion.com
Public Enquiries
Title Ms 
Last name Ashley 
First name Jaksa 
Address line 15 Penn Plaza 
Address line 27th Floor 
Address line 3 
CityNew York 
Postcode10001 
CountryUnited States 
Phone number (incl. country code)018448238466 
Alternative phone number 
Fax number (incl. country code) 
Email address ashley.jaksa@aetion.com 
Top